27 feb 2007

Presentación

¡Saludos, mentes inquietas!

Como sabéis, entre los días 11 y 21 del pasado mes de diciembre tuvieron lugar las conferencias del curso de humanidades organizado por Máximo Sandín "Biología para Principiantes". Dado el enorme interés que para muchos de nosotros suscitan los temas que se trataron, así como la falta de espacios y gente con la que compartir y desarrollar este interés, se planteó la propuesta de crear un blog mediante el cual todos los asistentes y ponentes pudiéramos mantenernos en contacto e intercambiar información, consultas abiertas, comentarios, artículos y discusiones.

La posibilidad de colgar comentarios a las entradas del blog está abierta a todo el mundo (visitantes), pero la creación de entradas* está reservada a los participantes del curso que se incluyeron en la lista que circuló el último día. A cada uno de ellos han llegado tres e-mails: Uno con la dirección para visitar y conocer el blog como visitante; otro de invitación a ser participante, para lo que es necesario abrir una cuenta de google si no se tiene ya (es muy muy sencillo y se hace todo en un santiamén en la página de enlace que ofrece el mensaje, pero no dudéis en plantear cualquier tipo de duda/inquietud que os pueda surgir escribiendo a retrotransponible@gmail.com); y un tercero de invitación al grupo de google "Bioprincipiantes".

Tanto en las entradas como en los comentarios pueden pegarse textos y enlaces a otras páginas, y en las entradas además pueden incluirse imágenes, pero desgraciadamente no se pueden adjuntar ficheros. Por esta razón se ha creado el grupo de google, donde podremos compartir a nuestro gusto y con discrección los materiales y documentos que deseemos.

Ninguno hemos encontrado un título para el blog más acertado que el del mismo curso. Lo que nos une es la intención y el deseo de observar, interpretar, e intentar comprender la vida ("hacer biología"), desde una perspectiva nueva y revolucionaria; por tanto, por el mero hecho de tratarse de una "perspectiva nueva", no podemos ser otra cosa que principiantes. Y por tanto, como sabiamente dijo Ángel Gabilondo, "quienes lo tengan todo muy claro que ni se acerquen".


*Una entrada es un mensaje como este, que al publicarse aparecerá en la portada del blog, y sobre el cual el resto de participantes y visitantes pueden colgar los comentarios que deseen. Cuando un miembro publica una entrada, el único dato personal que aparece es el pseudónimo con el que se haya inscrito en el blog.

37 comentarios:

Mosquita dijo...

Que ganas de hacer biología!
Solo quería comentar que merece la pena leer los articulos de evolución de la página de "evoluciónyambiente" para ir entrando en materia, sobre todo para aquellos que esten un poco peces en el tema

Anónimo dijo...

Yo no tengo claro esto: Si lo que dice este señor es verdad, ¿el darwinismo no vales?

Nature 445, 369 (25 January 2007) | doi:10.1038/445369a; Published online 24 January 2007
ConnectionsBiology's next revolution
Nigel Goldenfeld1 and Carl Woese2
1. Nigel Goldenfeld is in the Department of Physics and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, Illinois 61801, USA.
2. Carl Woese is in the Department of Microbiology and Institute for Genomic Biology, 601 South Goodwin Avenue, Urbana, Illinois 61801, USA.
Top of page
Abstract
The emerging picture of microbes as gene-swapping collectives demands a revision of such concepts as organism, species and evolution itself.
One of the most fundamental patterns of scientific discovery is the revolution in thought that accompanies a new body of data. Satellite-based astronomy has, during the past decade, overthrown our most cherished ideas of cosmology, especially those relating to the size, dynamics and composition of the Universe.

KAPUSTA
Similarly, the convergence of fresh theoretical ideas in evolution and the coming avalanche of genomic data will profoundly alter our understanding of the biosphere — and is likely to lead to revision of concepts such as species, organism and evolution. Here we explain why we foresee such a dramatic transformation, and why we believe the molecular reductionism that dominated twentieth-century biology will be superseded by an interdisciplinary approach that embraces collective phenomena.
The place to start is horizontal gene transfer (HGT), the non-genealogical transfer of genetic material from one organism to another — such as from one bacterium to another or from viruses to bacteria. Among microbes, HGT is pervasive and powerful — for example, in accelerating the spread of antibiotic resistance. Owing to HGT, it is not a good approximation to regard microbes as organisms dominated by individual characteristics. In fact, their communications by genetic or quorum-sensing channels indicate that microbial behaviour must be understood as predominantly cooperative.
In the wild, microbes form communities, invade biochemical niches and partake in biogeochemical cycles. The available studies strongly indicate that microbes absorb and discard genes as needed, in response to their environment. Rather than discrete genomes, we see a continuum of genomic possibilities, which casts doubt on the validity of the concept of a 'species' when extended into the microbial realm. The uselessness of the species concept is inherent in the recent forays into metagenomics — the study of genomes recovered from natural samples as opposed to clonal cultures. For example, studies of the spatial distribution of rhodopsin genes in marine microbes suggest such genes are 'cosmopolitan', wandering among bacteria (or archaea) as environmental pressures dictate.
Equally exciting is the realization that viruses have a fundamental role in the biosphere, in both immediate and long-term evolutionary senses. Recent work suggests that viruses are an important repository and memory of a community's genetic information, contributing to the system's evolutionary dynamics and stability. This is hinted at, for example, by prophage induction, in which viruses latent in cells can become activated by environmental influences. The ensuing destruction of the cell and viral replication is a potent mechanism for the dispersal of host and viral genes.
It is becoming clear that microorganisms have a remarkable ability to reconstruct their genomes in the face of dire environmental stresses, and that in some cases their collective interactions with viruses may be crucial to this. In such a situation, how valid is the very concept of an organism in isolation? It seems that there is a continuity of energy flux and informational transfer from the genome up through cells, community, virosphere and environment. We would go so far as to suggest that a defining characteristic of life is the strong dependency on flux from the environment — be it of energy, chemicals, metabolites or genes.
Nowhere are the implications of collective phenomena, mediated by HGT, so pervasive and important as in evolution. A computer scientist might term the cell's translational apparatus (used to convert genetic information to proteins) an 'operating system', by which all innovation is communicated and realized. The fundamental role of translation, represented in particular by the genetic code, is shown by the clearly documented optimization of the code. Its special role in any form of life leads to the striking prediction that early life evolved in a lamarckian way, with vertical descent marginalized by the more powerful early forms of HGT.
Refinement through the horizontal sharing of genetic innovations would have triggered an explosion of genetic novelty, until the level of complexity required a transition to the current era of vertical evolution. Thus, we regard as regrettable the conventional concatenation of Darwin's name with evolution, because other modalities must also be considered.
This is an extraordinary time for biology, because the perspective we have indicated places biology within a context that must necessarily engage other disciplines more strongly aware of the importance of collective phenomena. Questions suggested by the generic energy, information and gene flows to which we have alluded will probably require resolution in the spirit of statistical mechanics and dynamical systems theory. In time, the current approach of post-hoc modelling will be replaced by interplay between quantitative prediction and experimental test, nowadays more characteristic of the physical sciences.
Sometimes, language expresses ignorance rather than knowledge, as in the case of the word 'prokaryote', now superseded by the terms archaea and bacteria. We foresee that in biology, new concepts will require a new language, grounded in mathematics and the discoveries emerging from the data we have highlighted. During an earlier revolution, Antoine Lavoisier observed that scientific progress, like evolution, must overcome a challenge of communication: "We cannot improve the language of any science without at the same time improving the science itself; neither can we, on the other hand, improve a science without improving the language or nomenclature which belongs to it." Biology is about to meet this challenge.
Further reading
Frigaard, N., Martinez, A., Mincer, T. & DeLong, E. Nature 439, 847–850 (2006).
Sullivan, M. et al. PLoS Biol. 4, e234 (2006).
Pedulla, M. et al. Cell 113, 171–182 (2003).
Vetsigian, K., Woese, C. & Goldenfeld, N. Proc. Natl Acad. Sci. USA 103, 10696–10701 (2006).

Anónimo dijo...

Lo que podemos sacar en claro de las conclusiones de Woese tras décadas de investigación es que la evolución del mundo microbiano (que abarca la mayor parte de la historia de la vida y que aún hoy es el componente más importante de la biosfera y hace posible la existencia de los ecosistemas y las formas de vida pluricilulares)no puede entenderse o inteligirse mediante las hipótesis y el lenguaje que manejan el darwinismo y el neodarwinismo.

Emilio Cervantes dijo...

El darwinismo es más bien un cuento chino.

http://nuevabiologia.blogspot.com/

Anónimo dijo...

Y como dijo Margulis se ha acabado por convertir en una secta. Se pasan la vida atacando a la otra secta (los creacionistas) y venerando a su lider.

http://evolucionarios.blogalia.com/

De ciencia nada.

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